Review a VCF through the same pipeline used by the CLI.

The browser workflow reuses the existing ClinVar-first annotation, ranking, reporting, and export stack. It is designed for review, demonstration, and reproducible artifact generation, not for clinical operations.

Hosted runs write into isolated workspaces and the service reuses a shared processed ClinVar cache. The retention window of 24 hours applies to run workspaces, not to cache warm-up per query.

Start a run Review workflow details

Hosted demo profile

The site accepts a VCF upload, runs the shared pipeline, renders the generated HTML report, and exposes HTML, JSON, or Markdown exports from the completed run.

Input cap: 25 MB
Assemblies: GRCh37 / GRCh38
Retention window: 24h run cleanup

Input VCF

Accepts validated `.vcf` and `.vcf.gz` uploads up to 25 MB per submission.

Execution Shared

The web layer calls the same backend service, reporting code, and export generation paths as the CLI.

Outputs 3 Formats

Open the report in-browser or download the resulting HTML, JSON, or Markdown artifact after completion.

Run Setup

Submit a VCF, confirm the coordinate system, and choose whether the run should open in the browser or redirect straight to an export artifact.

VCF upload Use a local `.vcf` or `.vcf.gz` file. Uploaded inputs are isolated per run.

Assembly Pick the assembly that matches the uploaded VCF coordinates.

Options

Enable PharmGKB enrichment Skip browser report and go straight to export

Preferred export format Only used when "skip browser report" is selected.

Hosted process

The shared ClinVar cache is prepared ahead of time and reused across hosted runs. Individual uploads do not trigger a full cache build.

Run workspaces are temporary and may remain on disk until cleanup occurs. Do not submit protected health information or production patient data.

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